OBJECTIVE To observe the effects of Qingkailing on suppressor of cytokine signaling-3 (SOCS-3), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) in patients with cerebral vasospasm (CVS) after spontaneous subarachnoid hemorrhage (SAH). METHODS Sixty-eight patients with SAH were randomly assigned to treatment group (36 patients) and control group (32 patients).With routine treatment as the basic therapy, 30 ml of Qingkailing mixed into 100 ml of normal saline was intravenously dripped once daily to patients in treatment group.The drug was given immediately after disease onset, and continued for 21 days consecutively. The serum levels of SOCS-3, TNF-α and IL-6, transcranial Doppler sonography, glasgow outcome scale before and after treatment were compared between the two groups.RESULTS Compared with control group, the serum levels of hs-CRP, TNF-α and IL-6 decreased in the Qingkailing group (P<0.05), SOCS-3 increased (P<0.05). In middle cerebral artery (MCA), anterior cerebral artery (ACA) and posterior cerebral arteries (PCA), mean flow rate decreased (P<0.05), and GOS increased (P<0.05).CONCLUSION In patients with CVS after SAH, Qingkailing may increase the levels of SOCS-3, decrease the levels of TNF-α and IL-6 as well as cerebral blood flow rate, to alleviate cerebral vascular convulsion, and improve cerebral functions and prognosis. It is an effective agent for CVS in patients after SAH.